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Abstract
Background: The effects of gamma-aminobutyric (GABAA)-receptor ligands and peripheral-type benzo\diazepine (BZ) ligands on duodenal mucosal bicarbonate secretion (DBS) were studied in thiobarbiturate-anesthetized rats. Methods: A segment of proximal duodenum was perfused, and bicarbonate secretion was continuously titrated by pH-stat. In some experiments the vagus nerves were dissected free and cut at the neck level. Results: Luminal GABA (10-8 to 10-6 M) increased (P < 0.01) DBS dose-dependently, and the GABAA antagonist (+)-bicuculline (0.1-2.5 mg/kg intravenously) caused a similar increase (P