Gastric Myoelectric Activity in Patients with End-Stage Liver Disease

Abstract

Background: Abnormalities of gastrointestinal motility and transit time have been reported in association with end-stage liver disease. Motility abnormalities could be routinely studied if a simple noninvasive test were available. The electrogastrogram is a cutaneous measure of gastric myoelectric activity and correlates well with serosal recordings of gastric myoelectric activity. The aim of this study was to evaluate gastric myoelectric activity in patients with end-stage liver disease. Methods: Fourteen patients with end-stage liver disease had gastric myoelectric activity measured with the electrogastrogram. An electrogastrogram was considered abnormal when normal gastric slow waves were seen less than 70% of the time or there was no increase in the electrogastrogram amplitude after a meal. Results: Abnormal electrogastrograms were present in 8 of 14 (57%) end-stage liver disease patients. Conclusions: Abnormal gastric myoelectric activity is common in end-stage liver disease.