The effect of mannose binding lectin gene polymorphisms on susceptibility to tuberculosis in different ethnic groups

Hana M. El Sahly From the Department of Pathology, Baylor College of Medicine, Houston, Texas; From the Department of Medicine (Division of Infectious Diseases), Baylor College of Medicine, Houston, Texas

Robert A. Reich From the Department of Pathology, Baylor College of Medicine, Houston, Texas

Shu Jun Dou From the Department of Pathology, Baylor College of Medicine, Houston, Texas

James M. Musser From the Department of Pathology, Baylor College of Medicine, Houston, Texas; Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, USA

Edward A. Graviss From the Department of Pathology, Baylor College of Medicine, Houston, Texas; From the Department of Medicine (Division of Infectious Diseases), Baylor College of Medicine, Houston, TexasCorrespondence[email protected]

Abstract

In order to investigate the role of MBL gene polymorphisms in susceptibility to tuberculosis (TB) we genotyped 487 TB cases and 232 controls. Among African-American individuals, the frequency of B allele was lower among controls than cases (p<0.01), but we found no differences between cases and controls of white and Hispanic ethnicity.

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The effect of mannose binding lectin gene polymorphisms on susceptibility to tuberculosis in different ethnic groups

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The effect of mannose binding lectin gene polymorphisms on susceptibility to tuberculosis in different ethnic groups

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