Kinetics of Immune Parameters in a Patient with Sepsis Caused by Streptococcus pyogenes Treated with Activated Protein C

Michal Holub Third Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague, PragueCorrespondence[email protected])

Miroslav Helcl Department of Infectious Diseases of University Hospital Na Bulovce, Clinical and Experimental Endocrinology and Immunology, Prague

Ondřej Beran Wadsworth Center, Department of Health, Clinical and Experimental Endocrinology and Immunology, Albany

Jarmila Hnyková Third Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague, Prague

Jana Příhodová Department of Infectious Diseases of University Hospital Na Bulovce, Clinical and Experimental Endocrinology and Immunology, Prague

Abstract

We report a case of streptococcal sepsis treated with recombinant human activated protein C (rhAPC). High plasma IL-6 and cortisol levels at baseline significantly decreased 24 h following the infusion of rhAPC. This decrease was accompanied by a rise of circulating lymphocyte subsets. Our observation may be due to immunomodulatory properties of rhAPC.

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Kinetics of Immune Parameters in a Patient with Sepsis Caused by Streptococcus pyogenes Treated with Activated Protein C

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Kinetics of Immune Parameters in a Patient with Sepsis Caused by Streptococcus pyogenes Treated with Activated Protein C

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