Chron's Disease, Rare Association with Selective IgA Immunodeficiency, and Development of Life-threatening Bacterial Infections

Roberto Manfredi Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna ‘Alma Mater Studiorum’, S. Orsola Hospital, BolognaCorrespondence[email protected] or [email protected]

Olga V. Coronado Department of Otolaryngology, ‘Maggiore’ General Hospital, Bologna

Ginevra Marinacci Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna ‘Alma Mater Studiorum’, S. Orsola Hospital, Bologna

Mauro Righi Department of Otolaryngology, ‘Maggiore’ General Hospital, Bologna

Leonardo Calza Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna ‘Alma Mater Studiorum’, S. Orsola Hospital, Bologna

Abstract

Life-threatening necrotizing fasciitis and relapsing Lemierre syndrome associated with Fusobacterium necrophorum septicaemia occurred in young adults with a moderate Chron's disease and a missed profound IgA deficiency. This unexpected association of a chronic bowel inflammatory syndrome with prominent IgA abnormalities and severe bacterial infection deserves careful attention by physicians faced with young patients with Chron's disease.

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Chron's Disease, Rare Association with Selective IgA Immunodeficiency, and Development of Life-threatening Bacterial Infections

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Chron's Disease, Rare Association with Selective IgA Immunodeficiency, and Development of Life-threatening Bacterial Infections

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