Severe Metabolic Acidosis and Renal Failure in an HIV-1 Patient Receiving Tenofovir

Abstract

A 55-y-old male developed severe metabolic acidosis and renal failure during tenofovir therapy. Increased tenofovir exposure due to low body weight and chronic stable renal insufficiency could have enhanced the risk of nephrotoxicity, and creatinine clearance should be estimated before initiation of tenofovir.