Severe disseminated tuberculosis in a 4-month-old infant initially presenting with multiform cutaneous lesions

Nikos Spyridis From the Department of General Paediatrics, St Thomas’ Hospital, London, UK; Second Department of Paediatrics of the University of Athens, TB Clinic for Children, Aglaia Kyriakou Children's Hospital, Athens, GreeceCorrespondence[email protected]

Heleni Georgouli Second Department of Paediatrics of the University of Athens, TB Clinic for Children, Aglaia Kyriakou Children's Hospital, Athens, Greece

Theano Tsoukatou Second Department of Paediatrics of the University of Athens, TB Clinic for Children, Aglaia Kyriakou Children's Hospital, Athens, Greece

Irini Sakou Second Department of Paediatrics of the University of Athens, TB Clinic for Children, Aglaia Kyriakou Children's Hospital, Athens, Greece

Maria Tsolia Second Department of Paediatrics of the University of Athens, TB Clinic for Children, Aglaia Kyriakou Children's Hospital, Athens, Greece

Nikos Miriokefalitakis Second Department of Paediatrics of the University of Athens, TB Clinic for Children, Aglaia Kyriakou Children's Hospital, Athens, Greece

Panayiotis Spyridis Second Department of Paediatrics of the University of Athens, TB Clinic for Children, Aglaia Kyriakou Children's Hospital, Athens, Greece

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Abstract

A 4-month-old female infant presented with 1 month history of horizontal nystagmus and discrete multiform skin lesions. The patient was initially diagnosed with congenital nystagmus and staphylococcal skin infection not responding to antimicrobial agents. The development of severe systemic symptoms led to extensive investigations and the diagnosis of disseminated tuberculosis. Mycobacterium tuberculosis (MTB) was isolated from the skin and cerebrospinal fluid. The patient was treated with isoniazid, rifampicin, pyrizinamide, streptomycin and dexamethasone. Skin lesions resolved completely but severe neurological deficits persisted.

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Severe disseminated tuberculosis in a 4-month-old infant initially presenting with multiform cutaneous lesions

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Severe disseminated tuberculosis in a 4-month-old infant initially presenting with multiform cutaneous lesions

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