Drotrecogin alpha (activated) in neonatal septic shock

David Frommhold From the Division of Neonatology and 1Division of General Paediatrics, Department of Paediatrics, University of Heidelberg Medical School, Heidelberg, Germany

Alexandra Birle From the Division of Neonatology and 1Division of General Paediatrics, Department of Paediatrics, University of Heidelberg Medical School, Heidelberg, Germany

Otwin Linderkamp From the Division of Neonatology and 1Division of General Paediatrics, Department of Paediatrics, University of Heidelberg Medical School, Heidelberg, Germany

Eugen P. Zilow From the Division of Neonatology and 1Division of General Paediatrics, Department of Paediatrics, University of Heidelberg Medical School, Heidelberg, GermanyCorrespondence[email protected]

Johannes M.B. Pöschl From the Division of Neonatology and 1Division of General Paediatrics, Department of Paediatrics, University of Heidelberg Medical School, Heidelberg, Germany

Abstract

A 12-d-old neonate suffering from group B streptococcal septic shock was treated with 24 μg/kg/h recombinant human activated protein C [rhAPC, drotrecogin alpha (activated)] for 96 h. The protein C activity increased from 5% to 53% after rhAPC infusion. The patient recovered within 14 d without any adverse effects.

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Drotrecogin alpha (activated) in neonatal septic shock

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Drotrecogin alpha (activated) in neonatal septic shock

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