DNA sequence-based detection of group B Streptococcus directly from heart valve tissue in a patient with culture-negative endocarditis

Kelly Guggisberg From the Departments of Pathology & Laboratory Medicine, Calgary, Alberta, Canada

Robin Parker From the Departments of Pathology & Laboratory Medicine, Calgary, Alberta, Canada; Divisions of Anatomic Pathology, Calgary, Alberta, Canada

David Megran Medicine, Calgary, Alberta, Canada; Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada

Kunyan Zhang From the Departments of Pathology & Laboratory Medicine, Calgary, Alberta, Canada; Medicine, Calgary, Alberta, Canada; Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada; Microbiology, Calgary Laboratory Services, Calgary, Alberta, Canada

Wanda Lester From the Departments of Pathology & Laboratory Medicine, Calgary, Alberta, Canada; Divisions of Anatomic Pathology, Calgary, Alberta, Canada

Sameer Elsayed From the Departments of Pathology & Laboratory Medicine, Calgary, Alberta, Canada; Microbiology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada; Microbiology, Calgary Laboratory Services, Calgary, Alberta, CanadaCorrespondence[email protected]

Abstract

A human case of culture-negative bacterial endocarditis is presented where conventional methods failed to determine a microbial aetiology. DNA sequencing performed directly on autopsy heart valve tissue revealed Streptococcus agalactiae (group B streptococcus). To our knowledge, this is the first report of DNA sequence-based detection of this organism directly from a heart valve.

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DNA sequence-based detection of group B Streptococcus directly from heart valve tissue in a patient with culture-negative endocarditis

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DNA sequence-based detection of group B Streptococcus directly from heart valve tissue in a patient with culture-negative endocarditis

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