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Scandinavian Journal of Infectious Diseases Volume 39, 2007 - Issue 3
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CASE REPORT

First detection of a VIM-1 metallo-β-lactamase in a carbapenem-resistant Citrobacter freundii clinical isolate in an acute hospital in Germany

Jan Weile From the Department of Clinical Chemistry and Laboratory Medicine, Robert Bosch Hospital, Stuttgart, GermanyCorrespondence[email protected]
,
Harald Rahmig Department for Anaesthesiology and Intensive Care Medicine, Hospital Waiblingen, Waiblingen, Germany
,
Sabine Gfröer Institute for Laboratory Medicine, Marien Hospital, Stuttgart, Germany
,
Klaus Schroeppel From the Department of Clinical Chemistry and Laboratory Medicine, Robert Bosch Hospital, Stuttgart, Germany
,
Cornelius Knabbe From the Department of Clinical Chemistry and Laboratory Medicine, Robert Bosch Hospital, Stuttgart, Germany
&
Milorad Susa From the Department of Clinical Chemistry and Laboratory Medicine, Robert Bosch Hospital, Stuttgart, Germany
Pages 264-266 | Received 13 Jun 2006, Published online: 08 Jul 2009
 
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Abstract

We report the first detection of a carbapenem-resistant Citrobacter freundii clinical strain in Germany. It was isolated from an abscess of a patient with acute necrotic pancreatitis in an acute hospital. PCR and sequencing experiments revealed that the carbapenem resistance was mediated by a VIM-1 metallo-β-lactamase, located on a plasmid encoded class 1 integron. Carbapenem resistance in Enterobacteriaceae is so far a rare event and 1 of the major therapeutic concerns in the future.

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Related Research Data

Detection of VIM-1-producing Enterobacter cloacae and Salmonella enterica serovars Infantis and Goldcoast at a breeding pig farm in Germany in 2017 and their molecular relationship to former VIM-1-producing S. Infantis isolates in German livestock production.
Source: American Society for Microbiology
Carbapenem-resistant Citrobacter spp. isolated in Spain from 2013 to 2015 produced a variety of carbapenemases including VIM-1, OXA-48, KPC-2, NDM-1 and VIM-2.
Source: Oxford University Press (OUP)

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