Acute neurological events associated with influenza vaccination: Are the WHO criteria for assessing causality adequate?

Fotini D. Kavadas Department of Paediatrics, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada

Ari Bitnun From the Divisions of Infectious Diseases, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada; Department of Paediatrics, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, CanadaCorrespondence[email protected]

Daune MacGregor Neurology, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada; Department of Paediatrics, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada

Helen Heurter From the Divisions of Infectious Diseases, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada

E. Lee Ford Jones From the Divisions of Infectious Diseases, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada; Department of Paediatrics, The Hospital for Sick Children and The University of Toronto, Toronto, Ontario, Canada

Abstract

We identified neurological admissions temporally associated with influenza vaccine to determine the likelihood of causality using World Health Organization (WHO) criteria. Although all cases were categorized as possibly related to the vaccine, most had a compelling alternative explanation. This observation suggests that the current WHO criteria may not be sufficient in determining if an adverse event is truly vaccine related.

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Acute neurological events associated with influenza vaccination: Are the WHO criteria for assessing causality adequate?

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Acute neurological events associated with influenza vaccination: Are the WHO criteria for assessing causality adequate?

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