Success of ampicillin plus ceftriaxone rescue therapy for a relapse of Enterococcus faecalis native-valve endocarditis and in vitro data on double beta-lactam activity

José M. Miró From the Infectious Diseases Service, Microbiology Service,Correspondence[email protected]

Carlos Cervera From the Infectious Diseases Service, Microbiology Service,

Cristina García-de-la-Mària From the Infectious Diseases Service, Microbiology Service,

Ana Del Río From the Infectious Diseases Service, Microbiology Service,

Yolanda Armero From the Infectious Diseases Service, Microbiology Service,

Carlos A. Mestres Departments of Cardiovascular Surgery,

Jose M. Grau Internal Medicine, Hospital Clinic-IDIBAPSUniversity of Barcelona, Barcelona, Spain

Francesc Marco From the Infectious Diseases Service, Microbiology Service,

Asunción Moreno From the Infectious Diseases Service, Microbiology Service,

The Hospital Clinic Endocarditis Study Group From the Infectious Diseases Service, Microbiology Service,

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Abstract

We report a patient with Enterococcus faecalis native-valve endocarditis who relapsed after 4 weeks of treatment with ampicillin plus gentamicin. The relapse was cured with ampicillin plus ceftriaxone, which was introduced after gentamicin-induced acute renal failure. This double beta-lactam combination showed a bactericidal effect in time-killing curve studies.

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Success of ampicillin plus ceftriaxone rescue therapy for a relapse of Enterococcus faecalis native-valve endocarditis and in vitro data on double beta-lactam activity

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Success of ampicillin plus ceftriaxone rescue therapy for a relapse of Enterococcus faecalis native-valve endocarditis and in vitro data on double beta-lactam activity

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