Mechanism of Increased Serum Soluble Interleukin-2 Receptor Levels in Patients on Continuous Ambulatory Peritoneal Dialysis

Abstract

Objective: The aim of this study was to investigate the mechanism underlying the increase of serum soluble interleukin-2 receptor (IL-2R) levels in patients on continuous ambulatory peritoneal dialysis. Material and Methods: In 13 dialysis patients and 17 healthy controls, serum soluble IL-2R levels were determined by enzyme-linked immunosorbent assay, and CD25-positive (cell surface IL-2R-positive) cells were detected by flow cytometry. Soluble IL-2R levels were also measured in the supernatant of cultured peripheral blood mononuclear cells. Results: The serum soluble IL-2R level was significantly higher in the patients than in the healthy controls (p

• Continuous Ambulatory Peritoneal Dialysis Soluble Interleukin-2 Receptor Chronic Renal Failure Cd25 Peripheral Blood Mononuclear Cells