Effects of High Dose Medroxyprogesterone Acetate Treatment on Antithrombin III and other Plasma Proteins In Males With Renal Cell or Prostatic Carcinoma

Abstract

In 18 patients, 12 with renal cell and 6 with prostatic carcinoma treatment with high dose medroxyprogesterone acetate (MPA) significantly increased serum an-tithrombin III and haptoglobin concentrations. During treatment the proteins correlated with each others suggesting a response to similar regulatory mechanisms. Levels of orosomucoid, α₁-antitrypsin, Cl-inhibitor and von Wille-brand factor did not change during treatment showing that the increase of haptoglobin was not due to an acute-phase response. The increased antithrombin III levels may have a favourable impact on the frequency of thromboembolic complications during treatment with MPA.

Key Words:

• Medroxyprogesterone acetate
• Antithrombin III
• Haptoglobin
• Orosomucoid
• α₁-antitrypsin
• Cl-inhibitor
• Von Willebrand factor
• Renal cell carcinoma
• Prostatic carcinoma