Photophysical properties of pyridyloxy phthalocyanine encapsulated in nanoparticles

Abstract

Two aluminum chloride phthalocyanines with pyridyloxy substitution at α/β positions were synthesized. Their structures were characterized by infrared spectroscopy, proton nuclear magnetic resonance as well as elemental analysis. Tetra-α(β)-(2-pyridyloxy) aluminum chloride phthalocyanines were encapsulated into a diblock copolymer methoxy-poly(ethylene glycol)-block-poly(L-lysine) through a cosolvent method. The morphologies and photophysical properties of phthalocyanines encapsulated in nanoparticles were studied by transmission electron microscope, ultraviolet-visible, and fluorescence spectroscopic methods. The photophysical properties of phthalocyanines encapsulated into nanoparticles exhibited substitution positions dependence. The phthalocyanines with substitution at α positions were found to be an excellent candidate for use as photosensitizers for treatment of cancer by photodynamic therapy.

Keywords:

• Aluminum chloride phthalocyanine
• photophyscial properties
• poly(ethylene glycol)-block-poly(L-lysine)
• polymeric nanoparticles
• pyridyloxy

Additional information

Funding

This research was supported by the National Key Basic Research Program of China (973 project) [grant mumber 2015CB352006]; National Natural Science Foundation of China [grant number 61335011, 21274021]; Natural Science Foundation of Fujian [grant number 2015J01040, 2014Y050] and Fujian Province Educational Project A [grant number JA15124]; Scientific research innovation team construction program of Fujian Normal University [grant number IRTL 1702]; The college students’ innovative and entrepreneurial training program of Fujian province [grant number cxxl-2017151, 201710394074].