Proton Decoupled ¹⁹F NMR Spectroscopy of Drugs Used in Eye Treatment

Oddbjørn Sæther Department of Neuroscience, and Department of Physics, Norwegian University of Science and Technology (NTNU), Trondheim, NorwayCorrespondence[email protected]

Anna Midelfart Departments of Ophthalmology and Neuroscience, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Øystein Risa Department of Neuroscience, and Department of Physics, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Olav Haraldseth Department of Circulation and Medical Imaging, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Medical Imaging, St. Olav's Hospital, Trondheim, Norway

Jostein Krane Department of Chemistry, Norwegian University of Science and Technology (NTNU), Trondheim, Norway

Abstract

The potential for detecting fluorinated compounds in a 2.35 T nuclear magnetic resonance system was assessed to evaluate the possibility for in vivo monitoring of fluorinated drugs applied to the eye. Time‐share proton decoupled ¹⁹F NMR spectroscopy was implemented for signal enhancement in an experimental eye model. Signal‐to‐noise in ¹⁹F NMR spectra of dexamethasone phosphate was enhanced by 56%. However, decoupling did not enhance S/N for ciprofloxacin. The obtained detection limit of 0.1–0.2 µmol did not enable detection of drugs at therapeutic concentrations in the eye. Higher magnetic field and improved coil and detection technology might enable future in vivo monitoring of drugs in the eye.

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Proton Decoupled ¹⁹F NMR Spectroscopy of Drugs Used in Eye Treatment