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Applied Spectroscopy Reviews Volume 45, 2010 - Issue 3
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Original Articles

Application of Fourier Transform Infrared Spectrophotometry in Pharmaceutical Drugs Analysis

Andrei A. Bunaciu CROMATEC_PLUS SRL, Analytical Research Department, Bucharest, Romania
,
Hassan Y. Aboul-Enein Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, Dokki, Cairo, Egypt; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia
&
Serban Fleschin Department of Organic Chemistry, Faculty of Chemistry, University of Bucharest, Panduri, Bucharest, Romania
Pages 206-219 | Published online: 09 Feb 2010
 
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Abstract

This review provides some background to infrared spectroscopy including Fourier transform infrared spectroscopy. It is not meant to be complete or exhaustive but to provide the reader with sufficient background for selected applications in pharmaceutical analysis. Fourier transform infrared spectroscopy (FTIR) is a fast and nondestructive analytical method. Associated with chemometrics, it can become a powerful tool for the pharmaceutical industry. Indeed, it is suitable for analysis of solid, liquid, and biotechnological pharmaceutical forms. This review focuses on pharmaceutical FTIR applications used for qualitative and quantitative analysis. Moreover, it can be implemented during pharmaceutical development, in production for process monitoring, and in quality control laboratories.

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