Quantitative PMR Spectroscopy of Drigs in Pharmaceutical Forms. Determination of Fenfluramine, Diethylpropion, Methyldopa and 2-Acetoxy-4-Trifluoromethylbenzoic Acid

Abstract

The PMR tuchnique was applied to the quantitative analysis of some drugs, fenfluramine HCl, diethylpropion HCl, methyldopa and 2-acetoxy-4-trifluoromethyiberroic acid in pharmaceutical forms.

The proposed methods entails a minimum of procedural steps for the extraction of the active ingredients and it is based on the integration of selected proton resonances of the analyte and the internal standard.

Key Words:

• Quantitative ¹H NMR spectroscopy
• fenfluramine HCl
• diethylpropion HCl
• methyldopa
• 2-acetoxy-4-trifluorome-thylbenzoic- acid in pharmaceutical dosage forms