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Abstract
Summary - A rapid, accurate, precise and reproducible 1H-NMR assay and a direct UV one of ornidazole-bulk drug and tablet dosage forms are presented. The recoveries (Mean and S. D.%) by the 1H-NMR method were within 1% of those by the UV-method. The 1H-NMR method is based on the integration of the 2-methyl protons of ornidazole relative to that of the methyl protons of acetanilide (internal standard). The UV-method is based on the conjugated chromophoric nitroimidazole nucleus of ornidazole molecule. Moreover, very satisfactory mean recoveries for the bulk drug, added to its formulations, have been established.