Spectrophotometric Determination of Metoclopramide VIA Charge-Transfer Complexes

Abstract

Simple and sensitive spectrophotometric method for the determination of metoclopramide is described, based on the formation of charge-transfer complexes using chloranil and bromanil as π acceptors. These complexes exhibit intense absorption bands in the electronic spectrum. The molecular ratios of the reactants in the complexes were established and the experimental conditions leading to maximum charge-tranfer bands were also studied. The proposed procedure has been applied successfully to pure samples and drug formulations with good accuracy. The validity of the proposed method was checked by applying the standard addition technique in addition to a comparative study between its results and those obtained by the pharmacopoeial method.

Key Words:

• Metoclopramide
• Spectrophotometry
• Charge-transfer complexes
• Chloranil
• Bromanil