One Pot Synthesis of 1-Chloro-2-Chlorocarboxy-4H-Quinolizin-4-One and Its Derivatives

Abstract

Condensation of 2-pyridine acetic acid with thionyl chloride under reflux conditions generates the title compound in one step with >95% yield. Its reactivity toward alcohols and amines were investigated. All of the derivatives were characterized by NMR and MS analysis. One of its derivatives, 1-chloro-2-methoxycarboxy-4H-quinolizin-4-one, 5, was also characterized by X-ray diffraction studies.