Synthesis of Novel Optically Active Cyclic Phospholipid Conjugates of Tegafur and Uridine Starting From L-Serine

Zheng-Jie He The State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R. China

Wen-Bin Chen The State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R. China

Cheng-Xiang Zhang The State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R. China

Zheng-Hong Zhou The State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R. China

Chu-Chi Tang The State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, P. R. China

Abstract

Starting from L-serine, cyclic phospholids 2,3 and 4 were synthesized and successfully separated in the form of pure diastereomer. Their configurations were discussed and assigned according to their NMR spectra data. The asymmetric induction effects were also observed in two phosphorylation cyclizations.

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Synthesis of Novel Optically Active Cyclic Phospholipid Conjugates of Tegafur and Uridine Starting From L-Serine

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Synthesis of Novel Optically Active Cyclic Phospholipid Conjugates of Tegafur and Uridine Starting From L-Serine

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