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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 30, 2000 - Issue 6
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Original Articles

The Reaction of Ninhydrin with Trimethylbenzenes under Friedel-Crafts Reaction Conditions

, , , &
Pages 1057-1066 | Received 24 Feb 1999, Published online: 04 Dec 2007
 

Abstract

The reaction of ninhydrin with 1,2,3- and 1,2,4-trimethylbenzene in the presence of H2SO4 or AlCl3 afforded 2-monoaryl and 2,2-diaryl-1,3-indanedione derivatives as the major products. With 1,3,5-trimethylbenzene as the arene nucleophile, either a reduction product or an indenoindanone derivative was obtained depending upon the catalyst employed in the reaction.

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