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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 30, 2000 - Issue 19
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Original Articles

Efficient Synthesis of the C1-C8 Fragment of Reveromycins

Keith E. Drouet Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California, 92093-0358
,
Hung V. Tran Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California, 92093-0358
&
Emmanuel A. Theodorakis Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California, 92093-0358
Pages 3617-3628 | Received 15 Jan 2000, Published online: 04 Dec 2007
 
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Abstract

A stereocontrolled synthesis of the C1-C8 fragment of reveromycins is presented herein. Key to our strategy was the implementation of Evans' aldol reaction that delivered the desired stereochemistry at the C4 and C5 stereocenters.

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