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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 30, 2000 - Issue 1
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Original Articles

A Practical Synthesis of 1,4,7,10-Tetraaza-Cyclododecane, A Pivotal Precursor for MRI Contrast Agents

Marinella Ferrari Dipartimento di Chimica Organica e Industriale, Facoltà di Scienze MM.FF.NN., Via Venezian 21, 20133, Milano, Italy
,
Giovanni B. Giovenzana Dipartimento di Chimica Organica e Industriale, Facoltà di Scienze MM.FF.NN., Via Venezian 21, 20133, Milano, Italy
,
Giovanni Palmisano Dipartimento di Scienze Mediche, Facoltà di Farmacia, Viale Ferrucci 33, 28100, Novara, Italy
&
Massimo Sisti Dipartimento di Scienze Chimiche, Fisiche e Matematiche, Facoltà di Scienze MM.FF.NN., Via Lucini 3, 22100, Como, Italy Fax: E-mail: [email protected]
Pages 15-21 | Accepted 25 Apr 1999, Published online: 04 Dec 2007
 
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Abstract

A practical preparation of the versatile macrocycle 1,4,7,10-tetraazacyclododecane (cyclen) was developed starting from cheap and easily available starting materials as ethylenediamine and glyoxal.

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