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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 30, 2000 - Issue 1
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Original Articles

A Simple Method for the Functionalization of Naked Amino Hydroxymethylenebisphosphonic Acids via a Carbamate Bond

Marc Lecouvey Laboratoire de Chimie Structurale Biomoléculaire (UPRESA 7031-CNRS). UFR S.M.B.H. Université Paris-Nord. 74, Rue Marcel Cachin, 93017, Obigny, Cedex, France
&
Yves Leroux Laboratoire de Chimie Structurale Biomoléculaire (UPRESA 7031-CNRS). UFR S.M.B.H. Université Paris-Nord. 74, Rue Marcel Cachin, 93017, Obigny, Cedex, France
Pages 23-30 | Accepted 26 Apr 1999, Published online: 04 Dec 2007
 
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Abstract

A simple and efficient procedure for the synthesis of alkylcarbamate hydroxymethylenebisphosphonic acids is described. Hydroxylated compounds are activated with carbonyldiimidazole and coupled to naked amino hydroxymethylenebisphosphonic acids.

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