An Efficient “One Pot” Synthesis of Isoflavones

Sreenivasan Balasubramanian Department of Horticulture and National Food Safety and Toxicology Center, Bioactive Natural Products Laboratory, Michigan State University, East Lansing, Michigan, 48824

Muraleedharan G. Nair Department of Horticulture and National Food Safety and Toxicology Center, Bioactive Natural Products Laboratory, Michigan State University, East Lansing, Michigan, 48824

Abstract

Initial formation of deoxybenzoin 3 from phenyl acetic acid 1 and phenol 2 in the presence of BF₃.Et₂O followed by its treatment at room temperature with N, N'-dimethyl (chloromethylene) ammonium chloride, generated by reacting PCl₅ with DMF provides a mild and efficient route for a “one pot” synthesis of Isoflavones in high yields.

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An Efficient “One Pot” Synthesis of Isoflavones

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An Efficient “One Pot” Synthesis of Isoflavones

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