Synthesis of 4-(p-Methoxyphenyl)-β-Carboline, A New Inhibitor of Cellular Calcium Influx

Carl A. Busacca Dept. of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., P.O. Box 368, 900 Ridgebury Rd, Ridgefield, CT, 06877

Yong Dong Dept. of Chemical Development, Boehringer Ingelheim Pharmaceuticals Inc., P.O. Box 368, 900 Ridgebury Rd, Ridgefield, CT, 06877

Abstract

4-(p-methoxyphenyl)-β-carboline was prepared in four steps from indole. The key step involved palladium-catalyzed dehydrogenation of a dihydro-β-carboline dichlorophosphinic acid salt. The success of the dehydrogenation was found to depend on the catalyst support.

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Synthesis of 4-(p-Methoxyphenyl)-β-Carboline, A New Inhibitor of Cellular Calcium Influx

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Synthesis of 4-(p-Methoxyphenyl)-β-Carboline, A New Inhibitor of Cellular Calcium Influx

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