A Novel Method for Preparation of Trifluoromethyl Substituted 2,3-dihydro-1,4- diazepine and Benzimidazole

Qianli Chu Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, 200032, P.R., China

Yanli Wang Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, 200032, P.R., China

Shizheng Zhu Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, 200032, P.R., China

Abstract

Ethylenediamine reacted readily with 4-ethoxy-1,1,1-trifluoro-3-butene-2-one to form 5-trifluoromethyl-2,3-dihydro-1,4-diazepine in good yield. Under the same reaction conditions o-phenylene diamine gave 2-trifluoromethyl benzimidazole and benzimidazole.

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A Novel Method for Preparation of Trifluoromethyl Substituted 2,3-dihydro-1,4- diazepine and Benzimidazole

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A Novel Method for Preparation of Trifluoromethyl Substituted 2,3-dihydro-1,4- diazepine and Benzimidazole

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