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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 30, 2000 - Issue 16
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Original Articles

Trifluoromethylsulfenylation of Masked Carbonyl Compounds

S. Munavalli Geo-Centers, Inc., Gunpowder Branch, P. O. Box 68, Aberdeen Proving Ground, MD, 21010
,
D. K. Rohrbaugh U. S. Army, Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD, 21010
,
D. I. Rossman U. S. Army, Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD, 21010
,
F. J. Berg U. S. Army, Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD, 21010
,
G. W. Wagner U. S. Army, Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD, 21010
&
H. D. Durst U. S. Army, Edgewood Chemical Biological Center, Aberdeen Proving Ground, MD, 21010
Pages 2847-2854 | Accepted 19 Oct 1999, Published online: 04 Dec 2007
 
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Abstract

Incorporation of fluorine and fluorine containing groups such as trifluoromethyl and trifluoromethylthio moieties considerably enhances the biopharmacological properties of the parent precursors. Trifluoromethylsulfenylation of masked carbonyl functions, such as the enamines using N-(trifluoromethylthio)phthalimide is described in this communication.

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