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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 35, 2005 - Issue 16
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Original Articles

Sulphamic Acid—A Mild, Efficient, and Cost‐Effective Solid Acid Catalyst for the Synthesis of Bis(1H‐indol‐3‐yl)methanes

, &
Pages 2133-2138 | Received 02 May 2005, Published online: 18 Aug 2006
 

Abstract

Sulphamic acid (SA) is found to efficiently catalyze the electrophilic substitution reactions of indoles with aldehydes and ketones in ethanol to afford the corresponding bis(indolyl)methanes. The method is simple and cost effective, and gives good yields in short reaction times. The catalyst is found to be recyclable.

Acknowledgments

P.R.S. and D.U.S. thank the G. D. Gokhale Trust for the award of fellowships.

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