Synthesis of β‐Lactams: α‐Chloro and α‐Cyano β‐Lactams by Condensation of Imines with Titanium Ester Enolates Derived from Chloro and Cyano Ethyl Acetates

Abstract

α‐Cyano and α‐chloro β‐lactams are obtained in a one‐step reaction at a temperature of less than −78°C by condensation of imines with ester enolates derived from ethyl α‐cyano and α‐chloro acetates.

Keywords:

• α‐Cyano‐β‐lactams
• α‐chloro‐β‐lactams
• titanium enolates
• ester enolate–imine condensation

Acknowledgments

The authors are grateful to CSIR (New Delhi, India) for financial assistance.