Novel Synthesis of N‐Methyl Spiropyrrolidines by 1,3‐Dipolar Cycloaddition Reaction of Azomethine Ylides

Abstract

A series of novel N‐methyl spiropyrrolidines have been synthesized in good yield by the cycloaddition reaction of azomethine ylides generated by a decarboxylative route from sarcosine and paraformaldehyde with conformationally locked s‐trans enone functionality present in the (E)‐3‐arylidene‐4‐chromanone as dipolarophiles. The structure of the title compound was established by spectroscopic techniques.

Keywords:

• 1,3‐dipole
• azomethine
• ylide
• spiropyrrolidines

Acknowledgment

G.S. thanks the Council of Scientific and Industrial Research (CSIR), New Delhi, India, for the award of Senior Research Fellowship. Financial support from CSIR and University Grants Commission (UGC) is gratefully acknowledged.