Asymmetric Synthesis of β‐DDB Through Oxazoline‐Mediated Ullmann Coupling

Qitao Tan Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China

Hongyan Li Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China

Jiwu Wen Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China

Chen Jiang Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China

Xin Wang Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China

Tianpa You Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, ChinaCorrespondence[email protected]

Abstract

Biphenyl lignan (β‐DDB) (2), an effective drug in the treatment of hepatitis, was for the first time asymmetrically synthesized via a chiral oxazoline mediated Ullmann coupling. The two enantiomers of β‐DDB have been obtained in this way by using the optically pure amino alcohols L‐valinol and D‐valinol, respectively. However, attempts to synthesize enantiopure α‐DDB (1) by the same method failed because of the racemization of 1 at room temperature in solution.

Keywords:

Acknowledgment

We are grateful to the Natural Science Foundation of Anhui Province of China for financial support.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Asymmetric Synthesis of β‐DDB Through Oxazoline‐Mediated Ullmann Coupling

Information for

Open access

Opportunities

Help and information

Asymmetric Synthesis of β‐DDB Through Oxazoline‐Mediated Ullmann Coupling

Abstract

Acknowledgment

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature