Convenient Synthesis of 7,8‐Dimethoxytetralin‐2‐one

Abstract

7,8‐Dimethoxytetralin‐2‐one (1), an important intermediate for the synthesis of compounds possessing biological activity, was synthesized by simple reaction steps from commercially available starting materials.

Keywords:

• Cinnamic esters
• deethoxycarbonylation
• Dieckmann condensation
• 2‐tetralones

Acknowledgments

The authors are grateful to H. Medzihradszky‐Schweiger and her staff for the microanalyses, and to OTKA (Hungarian Academic Research Found Grant T 042491) and to Gedeon Richter Ltd. for financial assistance. The technical assistance of Attila Fürjes and Imre Sinka in recording the NMR spectra is gratefully acknowledged. Moreover, one of the authors (Á. G.) is indebted to József Varga Foundation for financial support.