Efficient Synthesis of 2‐(N‐Substituted)‐2‐imidazolines and 2‐(N‐Substituted)‐1,4,5,6‐tetrahydropyrimidines

Abstract

A general method for the preparation of 2‐(N‐Substituted)‐2‐imidazolines and 2‐(N‐Substituted)‐1,4,5,6‐tetrahydropyrimidines is described. These heterocycles can be synthesized from their respective anilines with 2‐chloro‐2‐imidazoline or 2‐chloro‐1,4,5,6‐tetrahydropyrimidine, generated in situ from imidazolidin‐2‐one and tetrahydropyrimidin‐2(1H)‐one activated by dimethyl chlorophosphate, in good to excellent yields.

Keywords:

• 2‐(N‐Substituted)‐2‐imidazolines
• 2‐(N‐substituted)‐1,4,5,6‐tetrahydropyrimidines

Acknowledgement

This work was supported by the National Science Council, Taiwan, R.O.C., Grant No. NSC92‐2113‐M415‐004.