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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 2
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Original Articles

New Synthesis of Donepezil Through Palladium‐Catalyzed Hydrogenation Approach

, , , , , & show all
Pages 169-174 | Received 11 Jul 2005, Published online: 15 Aug 2006
 

Abstract

A new, economical, and efficient process has been developed for large‐scale synthesis of donepezil 1, an anti‐Alzheimer's drug. The process involves palladium‐catalyzed hydrogenation of (2E)‐5,6‐dimethoxy‐2‐(pyridin‐4‐ylmethylene)indan‐1‐one 6 to provide 5,6‐dimethoxy‐2‐(piperidin‐4‐ylmethyl)indan‐1‐one 8 as a key step.

DRL‐IPD Communication No. 006.

Acknowledgment

The authors thank management of Dr. Reddy's Laboratories Ltd. for supporting this work. Cooperation from the project colleagues is highly appreciated.

Notes

DRL‐IPD Communication No. 006.

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