Acid‐Promoted Ring Opening of α‐Hydroxyl Cyclobutanones: A Novel and Facile One‐Pot Synthesis of Nitrile Derivatives

Abstract

A facile one‐pot synthesis of nitriles via a ring‐opening reaction of cyclobutanone adducts with hydroxylamine hydrochloride was developed.

Keywords:

• Cyclobutanone
• nitrile
• ring‐opening

Acknowledgments

Zhejiang Provincial Abroad Startup Foundation is gratefully acknowledged. We are also grateful for financial support from the National Outstanding Youth Fund (No. 29925204), the Foundation for University Key Teacher by the Ministry of Education of China, and a Visiting Fund of the National Laboratory of Applied Organic Chemistry.