Economical and Convenient Carbonyl Transposition Approach Toward a 2‐Arylcycloheptanone Derivative

Abstract

A convenient, straightforward, and easy access to 2(2,3‐dimethoxy‐phenyl)cycloheptanone, which employs an heteroatom‐facilitated ortho‐lithiation coupled to a carbonyl transposition strategy, is reported. The synthetic approach avoids using very expensive reagents or difficult‐to‐prepare starting materials.

Keywords:

• 2‐Arylcycloheptanone
• carbonyl transposition
• chemical synthesis
• epoxide rearrangement
• ortho‐lithiation

Acknowledgment

The authors gratefully acknowledge financial support provided by CONICET, Fundación Antorchas, and ANPCyT (Project 06‐12532) and also thank SECyT‐UNR. A. B. J. B. especially acknowledges ANPCyT and CONICET for her fellowship.