Syntheses of Pantolactone and Pantothenic Acid Derivatives as Potential Lipid Regulating Agents

Abstract

A series of pantolactone and pantothenic acid derivatives (1–10) were synthesized to be tested for their potential as lipid regulating agents that act as Coenzyme‐A mimics. The syntheses were performed with moderate to high yields.

Keywords:

• Pantolactone
• pantothenic acid
• coenzyme‐A
• dyslipidemia
• metabolic disorder

Acknowledgments

The authors thank Helene I. V. Amatdjais‐Groenen and Peter M. van Galen from the Catholic University of Nijmegen for performing the HRMS and CHN measurements. The authors also acknowledge Janell Lutostanski, Michelle Washburn, Martha Humes, Terri Bancero, and LeighAnn Jankowski for collection and analysis of biological samples.