One‐Pot, High‐Yielding Synthesis of Novel Dihydrothiazolo[3,2‐a]pyrimidinones

Dante Rotili Istituto Pasteur—Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Università degli Studi di Roma “La Sapienza,”, Rome, Italy

Antonello Mai Istituto Pasteur—Fondazione Cenci Bolognetti, Dipartimento di Studi Farmaceutici, Università degli Studi di Roma “La Sapienza,”, Rome, ItalyCorrespondence[email protected]

Ilaria Ambrogio Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi di Roma “La Sapienza,”, Rome, Italy

Giancarlo Fabrizi Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Università degli Studi di Roma “La Sapienza,”, Rome, Italy

Abstract

Reaction between 6‐(un)substituted‐2‐thiouracils and E‐ethyl 4‐bromocrotonate under basic conditions at room temperature is an easy, mild, high‐yielding, and regioselective method for the preparation of 7‐(un)substituted dihydrothiazolo[3,2‐a]pyrimidinone derivatives.

Keywords:

Acknowledgments

We gratefully acknowledge partial financial support from PRIN 2004 (to A. M.).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

One‐Pot, High‐Yielding Synthesis of Novel Dihydrothiazolo[3,2‐a]pyrimidinones

Information for

Open access

Opportunities

Help and information

One‐Pot, High‐Yielding Synthesis of Novel Dihydrothiazolo[3,2‐a]pyrimidinones

Abstract

Acknowledgments

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature