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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 3
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Abstracts

Graphical Abstracts

Pages i-vi | Published online: 19 Aug 2006
 

Abstract

Graphical Abstract Section

Abstract

Synth. Commun. 2006, 35, 259

NOVEL SYNTHESIS OF OPTICALLY ACTIVE 2‐ETHYLHEXANOIC ACID, 2‐ETHYLHEXANOL, AND 2‐ETHYLHEXYLAMINE VIA THE ASYMMETRIC FAVORSKII REARRANGEMENT

Motofumi Miura, Masaharu Toriyama, and Shigeyasu Motohashi

College of Pharmacy, Nihon University, Chiba, Japan

Abstract

Synth. Commun. 2006, 35, 265

ONE‐POT SUBSTITUTION‐REARRANGEMENT REACTION OF 2‐CHLOROGLYCIDIC ESTER: EFFECTIVE PROTOCOL FOR THE PREPARATION OF 3‐ARYLSULFENYL‐2‐KETO ESTER

Takuzo Komiyama, Yutaka Takaguchi, and Sadao Tsuboi

Department of Material and Energy Science, The Graduate School of Environmental Science, Okayama University, Okayama, Japan

Abstract

Synth. Commun. 2006, 35, 271

FAST SYNTHESIS OF SUBSTITUTED N‐PHENYLANTHRANILIC ACIDS USING ULLMANN CONDENSATION UNDER MICROWAVE IRRADIATION IN DRY MEDIA

Ana Martín, Miriam Mesa, Maite L. Docampo, Victoria Gómez, and Rolando F. Pellón

Center of Pharmaceutical Chemistry, Havana, Cuba

Substituted N‐phenylanthranilic acids using the Ullmann condensation under microwave irradiation in dry media were obtained in good yield and short reaction times.

Abstract

Synth. Commun. 2006, 35, 279

SYNTHESIS OF 4‐SUBSTITUTED PIPERIDINES VIA A MILD AND SCALABLE TWO‐STEP CU2O‐MEDIATED DECARBOXYLATION OF CYANOESTERS

Brian A. Chauder,1 Eric E. Boros,1 Kien S. Du,1 Wieslaw M. Kazmierski,1 Cecilia S. Koble,1 James B. Thompson,1 and Elie A. Tabet2

1Metabolic and Viral CEDD Chemistry, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, North Cardina, USA

2Chemical Development, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, NC, USA

Abstract

Synth. Commun. 2006, 35, 285

CONVENIENT METHOD FOR THE 3‐FUNCTIONALIZATION ISOINDAZOLES

Aaron Bunnell, Counde O'Yang, Andra Petrica, and Michael J. Soth

Department of Medicinal Chemistry, Roche Palo Alto LLC, Palo Alto, California, USA

The C‐3 position of isoindazoles is readily functionalized by metalation with lithium diisopropylamide followed by reaction with a variety of electrophiles.

Abstract

Synth. Commun. 2006, 35, 295

PREPARATION OF PRIMARY THIOAMIDES FROM NITRILES USING SODIUM HYDROGEN SULFIDE AND DIETHYLAMINE HYDROCHLORIDE

Mark L. Boys and Victoria L. Downs

Department of Chemistry, Pfizer Global R&D, Ann Arbor, Michigan, USA

Abstract

Synth. Commun. 2006, 35, 299

ECONOMICAL AND CONVENIENT CARBONYL TRANSPOSITION APPROACH TOWARDS A 2‐ARYLCYCLOHEPTANONE DERIVATIVE

Andrea B. J. Bracca and Teodoro S. Kaufman

Instituto de Química Orgánica de Síntesis (IQUIOS), Universidad Nacional de Rosario, Rosario, Argentina

A convenient, straightforward, and easy access to 2(2,3‐dimethoxyphenyl)cycloheptanone, which employs an heteroatom‐facilitated ortho‐lithiation coupled to a carbonyl transposition strategy, is reported. The synthetic approach avoids using very expensive reagents or difficult‐to‐prepare starting materials.

Abstract

Synth. Commun. 2006, 35, 311

NEW ACCESS TO SESQUITERPENE HYDROQUINONES: SYNTHESIS OF (+)‐ENT‐CHROMAZONAROL

José Villamizar,1 Federico Plata,1 Nieves Canudas,2 Eleonora Tropper,1 Juan Fuentes2 and Angel Orcajo1

1Centro de Química, Instituto Venezolano de Investigaciones Científicas (I.V.I.C.), Caracas, Venezuela

2Departamento de Química, Universidad Simón Bolívar, Valle de Sartenejas, Caracas, Venezuela

A facile access to optically active ( + )‐ent‐chromazonarol ent1, isolated from the sponge Disidea pallescens, is reported from commercially available ( + )‐manool 4.

Abstract

Synth. Commun. 2006, 35, 321

MICROWAVE‐ASSISTED BECKMANN REARRANGEMENT: CONVENIENT SYNTHESIS OF 1,3‐DIAZA‐BICYCLO[3.2.2]NONANE

Michael P. Curtis, William H. Bunnelle, Thomas G. Pagano, Murali Gopalakrishnan, and Ramin Faghih

Neuroscience Reasearch, Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois, USA

A convenient synthesis of 1,3‐diaza‐bicyclo[3.2.2]nonane using microwave irradiation was achieved.

Abstract

Synth. Commun. 2006, 35, 327

EFFICIENT PREPARATION OF HYBRID LINEAR‐BRANCHED ESTERS OF PEG‐PEE DERIVATIVES

Alexander Fishman, Austin Acton, and Edward Lee‐Ruff

Department of Chemistry, York University, Toronto, Ontario, Canada

A simple and efficient preparation of a number of hybrid linear‐branched PEG esters are described. The polymers are generated by direct coupling of PEG–carboxylic acids and a variety of pentaerythritol ethoxylates using carbon tetrabromide catalyst.

Abstract

Synth. Commun. 2006, 35, 331

BROMINATION PRODUCTS OF 2‐SUBSTITUTED 5,7‐DIMETHOXY‐4‐NAPHTHOLS

Ivan R. Green,1 Victor I. Hugo,2 and Mawonga N. Mei1

1Department of Chemistry, University of the Western Cape, Bellville, South Africa

2Department of Chemistry, Cape Peninsula University of Technology, Cape Town, South Africa

The influence of the R1 group of 13 and 21 on the major products 14 and 24 of bromination are described.

Abstract

Synth. Commun. 2006, 35, 347

EFFICIENT PREPARATION OF ((3‐CHLORO‐2‐FLUORO‐PHENYL)‐[7‐METHOXY‐8‐(3‐MORPHOLIN‐4‐YL‐PROPOXY)‐10,11‐DIHYDRO‐5‐OXA‐2,4,11‐TRIAZA‐DIBENZO(A,D)CYCLOHEPTEN‐1‐YL]‐AMINE) FOR IN‐VIVO STUDY

Hu Liu, Leon M. Smith II, Yunyu Mao, Weitao Pan, Yong‐Jiang Xu, Sabina Burdzovic‐Wizeman, Matthew A. J. Duncton, and Wai C. Wong

Department of Chemistry, ImClone Systems Incorporated, Brooklyn, New York, USA

An improved route for the preparation of highly functionalized 5,6‐dihydro‐pyrimido[4,5‐b][1,4]oxazepine 1a in multigram quantities was developed. This new methodology was highlighted by the proper methoxy disposition via a regioselective methylation of 2,4,5‐trihydroxy‐benzaldehyde followed by a magnesium sulfate–promoted cyclization.

Abstract

Synth. Commun. 2006, 35, 355

SYNTHESIS OF TETRAHYDOBENZAZEPINESULFONAMIDES AND THEIR REARANGEMENT TO DIARYLSULFONES

Hui Ren, Murray Zanger, and James R. McKee

Department of Chemistry & Biochemistry, University of the Sciences in Philadelphia, Philadelphia, PA, USA

The acid‐catalyzed rearrangement of benzodiazepinesulfonamides is used to prepare a new class of diarylsulfones, which may have anti‐HIV activity.

Abstract

Synth. Commun. 2006, 35, 365

SYNTHESES OF PANTOLACTONE AND PANTOTHENIC ACID DERIVATIVES AS POTENTIAL LIPID REGULATING AGENTS

Daniela C. Oniciu,1 Roel P. L. Bell,2 Bruce H. McCosar,3 Charles L. Bisgaier,1 Jean‐Louis H. Dasseux,1 Dennis Verdijk,2 Mike Relou,2 Dennis Smith,2 Henk Regeling,2 Frank M. C. Leemhuis,2 Eelco J. Ebbers,2 Ralf Mueller,3 Lian Hao Zhang,3 Emil Pop,3 Clay T. Cramer,1 Brian Goetz,1 Andrew McKee,3 Michael E. Pape,1 and Brian R. Krause1

1Esperion Therapeutics, Pfizer Global Research and Development, Ann Arbor, Michigan, USA

2MercaChem BV, Nijmegen, The Netherlands

3Alchem Laboratories Corporation, Alachua, Florida, USA

Abstract

Synth. Commun. 2006, 35, 393

CONDITION‐DIRECTABLE REACTION: REGIO‐ AND STEREOSELECTIVE ELIMINATION OF 2,3‐DIBROMO‐2‐METHYLPROPYL PHENYL SULFONE VIA BASE‐SOLVENT SELECTION

Xiaojin Li

Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA

Abstract

Synth. Commun. 2006, 35, 401

SYNTHESIS OF HOMOALLYLIC ALCOHOLS FROM KETONES IN WATER

Jun Wang and Gu Yuan

Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry, Peking University, Beijing, China

Homoallylic alcohols have been prepared in good yields by allylation of ketones with allyl bromide in the presence of stannous chloride dihydrate, zinc iodide, and ammonium chloride in water.

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