Facile and Practical Synthesis of (R)‐6‐Br‐2,2′‐bis(diphenylphosphino)‐1,1′‐binaphthyl

Abstract

A new enantiopure 6‐monobromo‐substituted BINAP has been prepared via a one‐step nickel‐catalyzed coupling reaction in moderate yield. It is an important intermediate for asymmetric 2,2′‐bis(diphenylphosphino)‐1,1′‐binaphthyl (BINAP) derivatives. Its structure was elucidated by NMR spectral and elemental analysis.

Keywords:

• Asymmetric reaction
• diphosphine ligand
• nickel‐catalyzed reaction

Acknowledgments

We are grateful to National Natural Science Foundation of China for the financial support (No. 29774012) and P. Hodge, Chemistry Department, Manchester University, for suggestions.