Stereocontrolled Transformations of trans α,β‐Aziridine Aldehydes toward Different Amino Hydroxylated Structures

Abstract

The stereocontrolled condensation of methyl ketones to trans α,β‐aziridine aldehydes creates functionalized aldols, valuable precursors for different amino hydroxylated structures, such as amino alcohols, amino diols, α‐tetrahydrofuryl amides, and α‐furyl amides.

Keywords:

• Aldol condensation
• amino alcohols
• amino diols
• α,β‐aziridine aldehydes
• α‐furyl amides

Acknowledgment

The authors thank MIUR (Ministry of University and Research, Rome) for partial financial support (Progect FIRB RBNE017F8 N).