Facile Synthesis of 2‐Alkylthio‐3‐alkyl‐5‐phenylmethylidene‐4H‐imidazol‐4‐ones

Abstract

2‐Alkylthio‐3‐alkyl‐5‐phenylmethylidene‐4H‐imidazol‐4‐ones 6 were synthesized by N‐alkylation and S‐alkylation of 2‐thioxo‐5‐phenylmethylidene‐4‐imidazolidinone 5, which was obtained via cyclization of vinyl isothiocyanate 4 with excess ammonium hydroxide (28% NH₃ in water).

Keywords:

• Alkylation
• aza‐Wittig reaction
• 4H‐imidazol‐4‐ones
• synthesis

Acknowledgments

We gratefully acknowledge financial support of this work by the Natural Science Foundation of Hubei Education Commission of China (Project No. D200560003) and the Natural Science Foundation of China (Project No. 20102001).