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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 15
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Original Articles

Efficient Synthesis of Bifenazate

Pages 2151-2156 | Received 27 Jan 2006, Published online: 16 Feb 2007
 

Abstract

The synthesis of bifenazate using a two‐step procedure has been accomplished with an overall yield of 26%. The procedure involved the Lewis acid–catalyzed electrophilic aromatic substitution of 4‐methoxybiphenyl with diisopropyl azodicarcoxylate (DIAD) to give a hydrazinedicarboxylate intermediate that was then subjected to a decarboxylation reaction to give bifenazate.

Acknowledgment

The author gratefully acknowledges Sheldon Park for helpful discussion and Wan Yu for providing analytical services.

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