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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 15
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Original Articles

Scalable Process for 4‐(2‐Hydroxy‐2‐methyl)‐ethyl‐benzylamine

, , , &
Pages 2145-2150 | Received 27 Jan 2006, Published online: 16 Feb 2007
 

Abstract

The preparation of the title compound has been revisited and improved. Starting from inexpensive cuminonitrile, 4‐(2‐hydroxy‐2‐methyl)‐ethyl‐benzylamine is obtained in a scalable two‐step process with an overall yield of 55%.

Acknowledgments

The authors thank R. Chambers for helpful discussions and D. Mendenhall and R. S. Ware for their analytical support.

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