Facile One‐Pot Synthesis of 3‐{2‐[5‐Hydroxy‐4‐(2‐hydroxy‐ethyl)‐3‐methyl‐pyrazol‐1‐yl]‐thiazol‐4‐yl}‐chromen‐2‐ones via a Three‐Component Reaction

Abstract

Reaction of 3‐(2‐bromo‐acetyl)‐chromen‐2‐one with thiosemicarbazide and 2‐acetylbutyro lactone in anhydrous ethanol gave 3‐{2‐[5‐hydroxy‐4‐(2‐hydroxy‐ethyl)‐3‐methyl‐pyrazol‐1‐yl]‐thiazol‐4‐yl}‐chromen‐2‐one in good yields.

Keywords:

• 2‐Acetylbutyrolactone
• benzopyran‐2‐one
• pyrazoles
• thiazoles

Acknowledgment

The authors are thankful to the head, RSIC, IIT Chennai, for analytical and spectral data. The authors also thank UGC, New Delhi, for the financial support (No. F‐12‐106/2001, SR‐I).