Isolation and Synthesis of Dibenzocyclooctadiene Lignans: (±)‐Schizandrin and Its Analogues

Abstract

Simple isolation of (±)‐schizandrin (1) and preparation of its analogues (6–8) via acylation of (±)‐schizandrin (1) are described. The key strategy in the synthesis involves the catalytic acylation reaction of 1 with several acylating reagents.

Keywords:

• Acylation
• dibenzocyclooctadiene lignans
• isolation
• (±)‐schizandrin

Acknowledgments

This project was supported by a grant/cooperative agreement from the Centers for Disease Control and Prevention (CDC). The U.S. Department of Agriculture, Agricultural Research Service Specifc Cooperative Agreement No. 58‐6408‐2‐0009 and Food and Drug Administration, FD‐U‐002071‐01 are acknowledged for partial support of this work.