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Synthetic Communications
An International Journal for Rapid Communication of Synthetic Organic Chemistry
Volume 36, 2006 - Issue 16
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Original Articles

Efficient Synthesis of 1‐(5′‐Acylamino‐1′,3′,4′‐thiadiazol‐2′‐yl)‐4‐acyl‐thiosemicarbazides

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Pages 2355-2362 | Published online: 22 Sep 2006
 

Abstract

Acyl chlorides reacted with ammonium thiocyanate and carbonic dihydrazide under phase‐transfer catalysis to first afford 2,2′‐bis(acylaminothiocarbonyl)‐carbonic dihydrazides, which further cyclized in the presence of glacial acetic acid to efficiently give 1‐(5′‐acylamino‐1′,3′,4′‐thiadiazol‐2′‐yl)‐4‐acyl‐thiosemicarbazides in high yield.

Acknowledgment

The authors thank the Chunhui Project of Ministry of Education of China (Z2004‐1‐62034) for the financial support of this work.

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